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just now (164+ words) Expert explores innovative strategies for managing early stage breast cancer, focusing on minimal residual disease and potential treatment adjustments. The primary recommendation for these patients is enrollment in clinical trials designed to test the efficacy of intensified or switched systemic therapies, with the goal of achieving MRD clearance and preventing overt recurrence. Unfortunately, there are no currently available data or guidelines to support the safe de-escalation or cessation of treatment based on ctDNA clearance or sustained negativity in the early-stage setting. The concept is highly promising but remains hypothetical and requires validation through prospective trials. In summary, ctDNA remains a powerful prognostic marker driving research, but its use as a directive for escalation or de-escalation of treatment is currently confined to the context of clinical trials. In an interview with Targeted Oncology, Stefania Morganti, MD, PhD, research fellow at the…...

just now (230+ words) Targeted Oncology connects oncology professionals with updates on immunotherapy, biomarkers, cancer pathways, and targeted precision medicine strategies. The field of circulating tumor DNA (ctDNA) for minimal residual disease (MRD) testing is experiencing rapid technological advancement, with new assays demonstrating increasing sensitivity by orders of magnitude compared to previous generations. This progress has generated significant excitement regarding its potential to revolutionize breast cancer management. The central challenge, however, remains the lack of proven clinical utility. While ctDNA is highly promising, particularly across the neoadjuvant, adjuvant, and even metastatic settings, its current function is primarily prognostic. Standard clinical practice currently relies on a probabilistic approach, estimating a patient's general risk of recurrence but it fails to provide the precise, individual-level risk stratification needed for personalized therapy selection. MRD testing offers the potential to move beyond probabilistic risk to a single-patient-level assessment of…...

just now (406+ words) A 20ft-tall naked man is once again surveying the people of Wigan, after previously being banned by the council. The statue, nicknamed "Golden Balls, had been erected outside a vintage shop until 2022, but had to be removed after neighbours complained. Its not quite Brazils Christ the Redeemer, but the stores owner Grant Adamson, 60, said customers were "heartbroken when it had to be removed six months after appearing. He has now put it back up in order to spread some "Christmas cheer. Wigan Council said they were "aware of its reappearance, and are assessing whether they need to take any action. The striking gold statue is of a Roman Gladiator, and was once used to promote the Russell Crowe blockbuster on this theme in 2000. You can now see it at Bulldog Forge, in Ince, Wigan, Greater Manchester. There had been a…...

just now (63+ words) The AFC South teams are all battling each other on Sunday, Nov. 30, and one of the matchups sees the Jacksonville Jaguars going against the Tennessee Titans at Nissan Stadium in Nashville, Tenn. Who: Jacksonville Jaguars vs. Tennessee Titans When: Sunday, Nov. 30 at 1 p.m. EST Where: Nissan Stadium in Nashville, Tenn. Stream: DIRECTV (free trial); FuboTV; Paramount+ (free trial); NFL+...

just now (355+ words) US Secretary of State Marco Rubio anticipated "more progress" from talks with Ukrainian officials Officials from the United States and Ukraine are currently engaged in peace negotiations aimed at resolving the war with Russia, it was confirmed on Sunday. Secretary of state Marco Rubio, special envoy Steve Witkoff and Jared Kushner, the US president's son-in-law, are holding discussions with a Ukrainian delegation to refine the 28-point peace plan proposed by Trump. Rustem Umerov, Ukraine's lead negotiator and secretary of the National Security and Defence Council, shared on X: "We have clear directives and priorities: safeguarding Ukrainian interests, ensuring substantive dialogue, and advancing on the basis of the progress achieved in Geneva." Mr Umerov added that their objective is to "secure real peace for Ukraine and reliable, long-term security guarantees." The Ukrainian delegation includes Andrii Hnatov, the head of Ukraine's armed forces;…...

just now (111+ words) KUCHING: A 63-year-old cyclist died in an alleged hit-and-run on Jalan Tanjung Lipat, Batu Niah, on Saturday (Nov 29) evening. Miri police chief ACP Mohd Farhan Lee Abdullah said the man was cycling from Pasar Batu Niah towards Kampung Tanjung Lipat at around 5.30pm when he was believed to have been struck by an oncoming vehicle. The victim died at the scene from severe injuries. The case is being investigated under Section 41(1) of the Road Transport Act 1987. Police are urging anyone with information to contact Investigating Officer Insp. Mohd Faizul Ab. Rahim at 014-8582582/ 085-430479 or visit the nearest police station. " Bernama...

just now (164+ words) "We apologize for the rain " it should not have been according to plan": US Secretary of State Marco Rubio apologized to the Ukrainian delegation for the bad weather in Florida during the meeting.At today's talks, he noted progress towards... "We apologize for the rain " it should not have been according to plan": US Secretary of State Marco Rubio apologized to the Ukrainian delegation for the bad weather in Florida during the meeting.At today's talks, he noted progress towards peace According to the US Secretary of State, we are talking about creating a long-term mechanism that will give Ukraine the opportunity to "never experience conflicts again.""We are continuing this very important work We achieved certain results not only in Geneva " progress was made there " but also throughout the week while we were negotiating The ultimate goal, of course,…...

1+ min ago (61+ words) Polish Prime Minister Donald Tusk could not restrain himself and told why NATO was created and is moving east.Zergulio Zergulio Sergey Kolyasnikov: Polish Prime Minister Donald Tusk could not restrain himself and told why NATO was created and is moving east Polish Prime Minister Donald Tusk could not restrain himself and told why NATO was created and is moving east....

1+ min ago (890+ words) No distractions: He doesn't follow sports on TV, never opens social media and, when he's really flowing, sends even the important calls to voicemail. Morgan Gendel's best work requires silence. "All I do," he said, "is walk around thinking of stuff." He's a professional " a career "idea man" " who's made his money by making things up. Gendel, paid to provide plots and new twists to blocked and bogged down TV writers in his 30s, became a Hollywood showrunner in his 40s. In his 60s, he thought up and patented a way to build low-cost, low-weight structures that could be used on NASA missions to the moon or Mars. And that latest idea is garnering attention. Now a 72-year-old adjunct professor of screenwriting at Old Dominion University, Gendel is building prototypes of his patented design for aerospace shelters on campus, with help from the…...

1+ min ago (542+ words) The Chiefs slipped to a 31-28 defeat to the Dallas Cowboys on November 28 The Kansas City Chiefs' 31-28 defeat to the Dallas Cowboys has intensified internal friction as Patrick Mahomes has grown increasingly frustrated after repeated defensive errors and penalties threaten to derail the team's playoff aspirations in 2025. The Chiefs now sit at 6-6 after 13 weeks, with their hopes for the AFC West effectively gone and their minimum expectations of reaching the NFL Playoffs quickly vanishing over the hill too. The locker room tension grew after a Week 11 loss to the Denver Broncos as veteran tight end Travis Kelce, who leads the team with 59 receptions for 719 yards and five touchdowns, remained silent with reporters. The discrepancy between yardage production and scoring has heightened Mahomes' frustration with the offensive support as the Chiefs rank second in receiving yards with 3,238 but fifth in scoring at…...